Resolution of Internal Carotid Arterial Thrombus by the Thrombolytic Action of Dabigatran
نویسندگان
چکیده
Non-vitamin K antagonist oral anticoagulants (NOACs) have been reported to cause resolution of intracardiac thrombus, but there have been no reported cases of internal carotid arterial thrombus resolution.We report a case of a 76-year-old man in whom an internal carotid arterial thrombus resolved after administration of the NOAC dabigatran at a dose of 110 mg twice daily.This is the first reported case of carotid arterial thrombus resolution after oral intake of NOAC (direct thrombin and factor Xa inhibitors), to the best of our knowledge.We conclude that this case had major clinical significance because it might represent one of the multiple effects of NOACs.
منابع مشابه
Molecular MRI of intracranial thrombus in a rat ischemic stroke model.
BACKGROUND AND PURPOSE Intracranial thrombus is a principal feature in most ischemic stroke, and thrombus location and size may correlate with outcome and response to thrombolytic therapy. EP-2104R is a fibrin-specific molecular MR agent that has previously been shown to enhance extracranial and venous sinus thrombi in animal models and, recently, in clinical trials. In this study, we examined ...
متن کاملMiddle cerebral artery occlusion in the rabbit using selective angiography: application for assessment of thrombolysis.
BACKGROUND AND PURPOSE An animal model of selective middle cerebral artery (MCA) occlusion is needed for evaluation of intra-arterial (IA) delivery of thrombolytic agents. We describe a technique for MCA thrombo-occlusion in the rabbit with real-time angiographic documentation of occlusion and thrombolytic recanalization. METHODS After femoral artery cutdown, a microcatheter was advanced from...
متن کاملComplex interventional treatment in patient with atrial fibrillation and stroke caused by large carotid artery thrombus- a case report
Introduction. The treatment option for acute ischemic stroke depends on the duration of symptoms, the dynamics of neurological condition changes, the etiology type of the stroke as well as results of angiographic and neuroimaging tests. Case presentation. In the paper, the case of Caucasian 60-year old male patient was presented with progressive left hemisphere stroke caused by extensive cardio...
متن کاملThrombolytic Effects of Recombinant Fibrolase
Background Thrombolytic agents used clinically rely on the activation of plasminogen to plasmin. Plasmin possesses multiple actions including increasing thrombin activity and activation of platelets. Thus, after successful thrombolytic therapy, arterial hyperactivity and reocclusion may be the result of a predominant plasmin-induced thrombogenic action at the site of the residual thrombus. Fibr...
متن کاملComplex interventional treatment in a patient with atrial fibrillation and stroke caused by large carotid artery thrombus: a case report
BACKGROUND The treatment option for acute ischaemic stroke depends on the duration of symptoms, the dynamics of neurological condition changes, the aetiology, type of stroke, as well as the results of angiographic and neuroimaging tests. CASE PRESENTATION A 60-year-old male patient presented with progressive left hemisphere stroke caused by extensive cardiogenic embolism of the common carotid...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره 95 شماره
صفحات -
تاریخ انتشار 2016